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Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammat...
Abstract Objective The goal of this study was to explore the role of bradykinins and bradykinin 1 receptor (B1R) in murine lupus nephritis. Methods C57BL/6 and MRL/lpr mice were... -
Real-world efficacy and safety of nivolumab in previously-treated metastatic ...
Abstract Background The Italian Renal Cell Cancer Early Access Program was an expanded access program that allowed access to nivolumab, for patients (pts) with metastatic renal... -
PRODIG (Prevention of new onset diabetes after transplantation by a short ter...
Abstract Background Post-transplant diabetes is a frequent and serious complication of kidney transplantation. There is currently no treatment to prevent or delay the disease.... -
Epidemiology of gout in Hong Kong: a population-based study from 2006 to 2016
Abstract Objective To determine the incidence and prevalence of gout in the general population and the utilisation of urate-lowering therapy (ULT) among patients with gout in... -
Adverse events profile of oral corticosteroids among asthma patients in the U...
Abstract Background To evaluate the adverse events profile of oral prednisolone among adult asthma patients in the UK. Methods Using data from the UK-based Clinical Practice... -
Platelet activation independent of pulmonary inflammation contributes to dies...
Abstract Background Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet... -
Bright and photostable single-photon emitter in silicon carbide
Single-photon sources are of paramount importance in quantum communication, quantum computation, and quantum metrology. In particular, there is great interest in realizing... -
Ochratoxin A induces liver inflammation: involvement of intestinal microbiota
Abstract Background Ochratoxin A (OTA) is a widespread mycotoxin and induces liver inflammation to human and various species of animals. The intestinal microbiota has critical... -
Balanced crystalloids versus saline in the intensive care unit: study protoco...
Abstract Background Saline, the intravenous fluid most commonly administered to critically ill adults, contains a high chloride content, which may be associated with acute... -
TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-depend...
Abstract Background Dysregulated transforming growth factor β (TGFβ) signaling is implicated in osteoarthritis development, making normalizing TGFβ signaling a possible therapy....
