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Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...
Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Identification of plasma microRNA expression changes in multiple system atrop...
Abstract MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The... -
Examining the role of unmeasured confounding in mediation analysis with genet...
Abstract Background In mediation analysis if unmeasured confounding is present, the estimates for the direct and mediated effects may be over or under estimated. Most methods... -
Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte d...
Abstract Background Emerging evidence suggests that microRNAs (miRs) are associated with the progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p... -
Multiphoton in vivo imaging with a femtosecond semiconductor disk laser
We use an ultrafast diode-pumped semiconductor disk laser (SDL) to demonstrate several applications in multiphoton microscopy. The ultrafast SDL is based on an optically pumped... -
Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal t...
Abstract Background Tumor microenvironments (TMEs) activate various axes/pathways, predominantly inflammatory and hypoxic responses, impact tumorigenesis, metastasis and... -
Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and s...
Abstract Background Cesium-137 (137Cs) is one of the major and most clinically relevant radionuclides of concern in a radiological dispersal device, “dirty bomb” scenario as... -
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain cri...
Abstract Background The accumulation of soluble oligomeric amyloid-β peptide (oAβ) proceeding the formation of senile plaques contributes to synaptic and memory deficits in... -
Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the prot...
Abstract Objective The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in... -
A novel method for the quantification of fatty infiltration in skeletal muscle
Abstract Background Fatty infiltration of the skeletal muscle is a common but poorly understood feature of many myopathies. It is best described in human muscle, where... -
MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy an...
Abstract Background In diabetes mellitus the morbidity and mortality of cardiovascular disease is increased and represents an important independent mechanism by which heart... -
Influenza A virus enhances ciliary activity and mucociliary clearance via TLR...
Abstract Background Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are... -
The protective effects of Resveratrol against radiation-induced intestinal in...
Abstract Background Intestinal injury is a potential cause of death after high-dose radiation exposure. The aim of the present study was to investigate the protective effects of... -
Tumor-suppressor role of miR-139-5p in endometrial cancer
Abstract Background Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical... -
Noninvasive label-free imaging of microhemodynamics by optical-resolution pho...
In vivo microcirculatory imaging facilitates the fundamental understanding of many major diseases. However, existing techniques generally require invasive procedures or... -
Effect of withholding early parenteral nutrition in PICU on ketogenesis as po...
Abstract Background In critically ill children, omitting early use of parenteral nutrition (late-PN versus early-PN) reduced infections, accelerated weaning from mechanical... -
The relationship between foot arch measurements and walking parameters in chi...
Abstract Background Walking mechanics are influenced by body morphology. Foot arch height is one aspect of body morphology central to walking. However, generalizations about the... -
Computed tomography derived bone density measurement in the diabetic foot
Abstract Background The accurate and reliable measurement of foot bone density is challenging and there is currently no gold standard technique. Such measurement is particularly... -
Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of t...
Abstract Background Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner....
