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Effects of cigarette smoke on barrier function and tight junction proteins in...
Abstract Background Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes... -
Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK sign...
Abstract Background Our previous study showed Musashi2 (MSI2) promoted chemotherapy resistance and pernicious biology of pancreatic cancer (PC) by down-regulating Numb and p53.... -
The human fetal adrenal produces cortisol but no detectable aldosterone throu...
Abstract Background Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth... -
Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and s...
Abstract Background Cesium-137 (137Cs) is one of the major and most clinically relevant radionuclides of concern in a radiological dispersal device, “dirty bomb” scenario as... -
Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role ...
Abstract Background The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived... -
Efficacy and safety of Ding-Kun-Dan for female infertility patients with pred...
Abstract Background Women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) who have a predicted poor ovarian response (POR) present a challenge... -
A randomized controlled trial protocol comparing the feeds of fresh versus fr...
Abstract Background Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at -
Comparison of the effects of Crataegus oxyacantha extract, aerobic exercise a...
Abstract Background Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was comparing the effect of... -
Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifest...
Abstract Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive... -
Normal fertilisation rates and serum 25-OHD levels among couples undergoing i...
Abstract Background The aim of this study was to explore the correlation between serum vitamin D levels in couples undergoing in-vitro fertilisation (IVF) and normal... -
Hypercapnic acidosis attenuates pulmonary epithelial stretch-induced injury v...
Abstract Background Hypercapnia, with its associated acidosis (HCA), is a consequence of respiratory failure and is also seen in critically ill patients managed with... -
Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and en...
Abstract Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a... -
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar chara...
Abstract The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs... -
Changes in circulating cell-free nuclear DNA and mitochondrial DNA of patient...
Abstract Background Adolescent idiopathic scoliosis (AIS) which characterized by complex three-dimensional deformity of spine has been difficult to cure because of the unknown... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Association between factors related to the pregnancy, neonatal period, and la...
Abstract Background Studies about the majority of the factors that may potentially influence the pubertal timing and menarche were controversial. The objective was to evaluate... -
MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mi...
Abstract Background Mitochondrial Ca2+ plays a critical role in tumorigenesis, including cell proliferation and metastasis. Mitochondrial calcium uniporter regulator 1 (MCUR1)... -
Development of a high-throughput screen to identify small molecule enhancers ...
Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane... -
[18F]tetrafluoroborate as a PET tracer for the sodium/iodide symporter: the i...
Abstract Background [18F]BF4 −, the first 18F-labelled PET imaging agent for the sodium/iodide symporter (NIS), was produced by isotopic exchange yielding a product with limited...
