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Neutrophil extracellular traps induce aggregation of washed human platelets i...
Abstract Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host... -
Obesity-induced cardiac lipid accumulation in adult mice is modulated by G pr...
Abstract Background The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular... -
Glucocorticoids promote transition of ductal carcinoma in situ to invasive du...
Abstract Background The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of... -
Progranulin derivative Atsttrin protects against early osteoarthritis in mous...
Abstract Background Atsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in... -
Dynamic OCT measurement of corneal deformation by an air puff in normal and c...
A new technique is presented for the non-invasive imaging of the dynamic response of the cornea to an air puff inducing a deformation. A spectral OCT instrument combined with an... -
Intraflagellar transport proteins are involved in thrombocyte filopodia forma...
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary... -
Agonist-induced activation of human FFA1 receptor signals to extracellular si...
Abstract Background FFA1 is abundantly expressed in the liver, skeletal muscle, monocytes and nervous system, but is particularly abundant in pancreatic β cells. It is widely... -
Air pollution-induced placental epigenetic alterations in early life: a candi...
Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. Air pollution's adverse effects are known to alter gene expression... -
Structurally isolated photoactuation of graphene-mixed temperature-responsive...
Abstract This paper presents fabrication and actuation methods for a soft microrobot with a hybrid structure composed of soft microactuators and a rigid supporting body. This... -
CYP1A1 methylation mediates the effect of smoking and occupational polycyclic...
Abstract Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the... -
Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular ...
Abstract Background In sepsis, the endothelial barrier becomes incompetent, with the leaking of plasma into interstitial tissues. VE-cadherin, an adherens junction protein, is... -
Transgenic Expression of miR-222 Disrupts Intestinal Epithelial Regeneration ...
Abstract Defects in intestinal epithelial integrity occur commonly in various pathologies. miR-222 is implicated in many aspects of cellular function and plays an important role... -
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by ...
Abstract Background Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an... -
Severe burn injury alters intestinal microbiota composition and impairs intes...
Abstract Background The intestinal barrier integrity is crucial for maintaining intestinal homeostasis, and the mechanisms of intestinal barrier disruption induced by burn... -
De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy ...
Abstract Background Sphingolipids are important for innate immune response to eliminate infected pathogens and involved in autophagy. On the other hand, nucleotide-binding... -
A T-type channel-calmodulin complex triggers αCaMKII activation
Abstract Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and... -
Proximal tibial trabecular bone mineral density is related to pain in patient...
Abstract Background Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis... -
The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies
Abstract Background Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include the infiltration of... -
Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hype...
Abstract Cav3.2Â T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral...
