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Humoral and cellular immune responses induced by the urease-derived peptide J...
Abstract Background Although the entomotoxicity of plant ureases has been reported almost 20Â years ago, their insecticidal mechanism of action is still not well understood.... -
Ochratoxin A induces liver inflammation: involvement of intestinal microbiota
Abstract Background Ochratoxin A (OTA) is a widespread mycotoxin and induces liver inflammation to human and various species of animals. The intestinal microbiota has critical... -
Human mesenchymal stromal cells inhibit platelet activation and aggregation i...
Abstract Background Mesenchymal stromal cells (MSCs) are promising cell therapy candidates. Clinical application is considered safe. However, minor side effects have included... -
Murine sepsis phenotypes and differential treatment effects in a randomized t...
Abstract Background Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in... -
Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated pat...
Abstract Background High-permeability pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid... -
Association between pre-pregnancy body weight and dietary pattern with large-...
Abstract Background Both obesity and gestational diabetes (GDM) are associated with adverse outcomes. Diet during pregnancy impacts weight gain and fetal growth. Therefore, we... -
Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage exp...
Abstract Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD). In vitro... -
Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and ...
Abstract Background Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic,... -
Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabete...
Abstract Background The effect of glucagon-like peptide-1(GLP-1) receptor agonists on heart failure remains uncertain. We therefore conducted a systematic review to assess the... -
Evaluation of anaesthesia and analgesia quality during disbudding of goat kid...
Abstract Background Certified Swiss farmers are allowed to disbud their goat kids using a standard intramuscularly administered anaesthetic mixture. This mixture, containing... -
Public release of hospital quality data for referral practices in Germany: re...
Abstract Objective To evaluate the impact of different dissemination channels on the awareness and usage of hospital performance reports among referring physicians, as well as... -
Using smartphones to decrease substance use via self-monitoring and recovery ...
Abstract Background Alcohol abuse, other substance use disorders, and risk behaviors associated with the human immunodeficiency virus (HIV) represent three of the top 10... -
Cerebellar involvement in Parkinson’s disease resting tremor
Abstract Background There exists a lack of consensus regarding how cerebellar over-activity might influence tremor in Parkinson’s disease (PD). Specifically, it is unclear... -
Shifts in FGM/C practice in Sudan: communities’ perspectives and drivers
Abstract Background Although Sudan has one of the highest prevalence of female genital mutilation or cutting (FGM/C), there have been shifts in e practice. These shifts include... -
Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated...
Abstract Despite the potent antiinflammatory effects of pharmacologically induced adenosine 5′-monophosphate kinase (AMPK) activation on Toll-like receptor 4 (TLR4)-induced... -
Base excess and hematocrit predict response to indomethacin in very low birth...
Abstract Background The treatment of patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants remains a challenge. The ability to predict which infants will...
