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Millstone: software for multiplex microbial genome analysis and engineering
Abstract Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial... -
Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying t...
Abstract Background Squalene is currently used widely in the food, cosmetics, and medicine industries. It could also replace petroleum as a raw material for fuels. Microbial... -
Identifying the effect of patient sharing on between-hospital genetic differe...
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient... -
Light-induced gene expression with photocaged IPTG for induction profiling in...
Abstract Background Inducible expression systems are frequently used for the production of heterologous proteins. Achieving maximum product concentrations requires induction... -
Polarization-sensitive swept-source optical coherence tomography with continu...
We present fiber-based polarization-sensitive swept-source optical coherence tomography (SS-OCT) based on continuous source polarization modulation. The light source is a... -
Dynamic light sheet generation and fluorescence imaging behind turbid media
Abstract Background Light sheet microscopy became a popular tool allowing fast imaging with reduced out of focus light. However, when light penetrates turbid media such as... -
Evaluation of novel inducible promoter/repressor systems for recombinant prot...
Abstract Background Engineering lactic acid bacteria (LAB) is of growing importance for food and feed industry as well as for in vivo vaccination or the production of... -
Public health surveillance in the UK revolutionises our understanding of the ...
Abstract Background The ST313 sequence type of Salmonella Typhimurium causes invasive non-typhoidal salmonellosis and was thought to be confined to sub-Saharan Africa. Two... -
2-D PSTD Simulation of optical phase conjugation for turbidity suppression
Turbidity Suppression via Optical Phase Conjugation (TS-OPC) is an optical phenomenon that uses the back propagation nature of optical phase conjugate light field to undo the... -
Visualization of activity-regulated BDNF expression in the living mouse brain...
Abstract Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to understand how the... -
Salmonella Typhimurium undergoes distinct genetic adaption during chronic inf...
Abstract Background Typhoid fever caused by Salmonella enterica serovar Typhi (S. Typhi) is a severe systemic human disease and endemic in regions of the world with poor... -
Unequal representation of genetic variation across ancestry groups creates he...
Abstract An important application of modern genomics is diagnosing genetic disorders. We use the largest publicly available exome sequence database to show that this key... -
Increase in oxidative stress levels following welding fume inhalation: a cont...
Abstract Background Tungsten inert gas (TIG) welding represents one of the most widely used metal joining processes in industry. It has been shown to generate a large majority...
