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Allergen immunotherapy for IgE-mediated food allergy: protocol for a systemat...
Abstract Background The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for... -
The effect of polymyxin B hemoperfusion on modulation of human leukocyte anti...
Abstract Background Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear... -
Contribution of a synchronic teleneurology program to decrease the patient nu...
Abstract Backround There is a shortage of medical specialists in Chile, including neurologists; currently, there are 56,614 patients waiting for a first adult Neurology... -
Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibr...
Abstract Background Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous... -
MEN1 redefined, a clinical comparison of mutation-positive and mutation-negat...
Abstract Background Multiple Endocrine Neoplasia type 1 (MEN1) is diagnosed when two out of the three primary MEN1-associated endocrine tumors occur in a patient. Up to 10–30 %... -
Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of u...
Abstract Background Type 2 helper T-cell cytokines including IL-13 play a central role in the pathogenesis of bronchial asthma (BA). During the course of our research, our... -
Access to reperfusion therapy and mortality outcomes in patients with ST-segm...
Abstract Background Evidence on access to reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI) and associated mortality in developing... -
Virulence factor RNA transcript expression in the Leishmania Viannia subgenus...
Abstract Background Leishmania RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20–25% of Viannia—species endemic to Latin America, and is believed to accelerate... -
Pharmacokinetic and safety profile of tofacitinib in children with polyarticu...
Abstract Background Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study... -
Summary of anti-malarial prophylactic efficacy of tafenoquine from three plac...
Abstract Background Tafenoquine is a long half-life primaquine analog being developed for malaria prophylaxis. The US Army recently performed a unified analysis of efficacy in... -
Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
Abstract Background A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis.... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
Re-programming of Pseudomonas syringae pv. actinidiae gene expression during ...
Abstract Background Pseudomonas syringae is a widespread bacterial species complex that includes a number of significant plant pathogens. Amongst these, P. syringae pv.... -
Therapeutic potential of mesenchymal stem cells and their exosomes in severe ...
Abstract The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing... -
Superficial zone cellularity is deficient in mice lacking lubricin: a stereos...
Abstract Background Lubricin, a mucinous glycoprotein secreted by synoviocytes and chondrocytes plays an important role in reducing the coefficient of friction in mammalian... -
GSTU43 gene involved in ALA-regulated redox homeostasis, to maintain coordina...
Abstract Background Exogenous 5-aminolevulinic acid (ALA) positively regulates plants chlorophyll synthesis and protects them against environmental stresses, although the... -
Comparison of two methods of collecting healthcare usage data in chiropractic...
Abstract Background The use of patient-reported questionnaires to collect information on costs associated with routine healthcare services, such as chiropractic, represents a... -
The interferon-induced antiviral protein PML (TRIM19) promotes the restrictio...
Abstract Background The promyelocytic leukemia (PML) protein, a type I interferon (IFN-I)-induced gene product and a member of the tripartite motif (TRIM) family, modulates the... -
Evidence of cAMP involvement in cellobiohydrolase expression and secretion by...
Abstract Background The signaling second messenger cyclic AMP (cAMP) regulates many aspects of cellular function in all organisms. Previous studies have suggested a role for... -
Evaluating the efficacy of dexamethasone in the treatment of patients with pe...
Abstract Background Although much has evolved in our understanding of the pathogenesis and factors affecting outcome of patients with acute respiratory distress syndrome (ARDS),...
