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Dimethyl fumarate attenuates reactive microglia and long-term memory deficits...
Abstract Background Systemic inflammation is associated with increased cognitive decline and risk for Alzheimer’s disease. Microglia (MG) activated during systemic inflammation... -
Sucroferric oxyhydroxide decreases serum phosphorus level and fibroblast grow...
Abstract Objective Sucroferric oxyhydroxide, a novel iron-based phosphate-binder, has been shown to have beneficial effects in lowering serum phosphorus levels and improving... -
Inhibition of Salmonella Typhimurium adhesion, invasion, and intracellular su...
Abstract Salmonella enterica serovar Typhimurium infects intestinal epithelia and macrophages, which is prevented by inhibiting adhesion and cell invasion. This study aimed to... -
Multiphoton in vivo imaging with a femtosecond semiconductor disk laser
We use an ultrafast diode-pumped semiconductor disk laser (SDL) to demonstrate several applications in multiphoton microscopy. The ultrafast SDL is based on an optically pumped... -
Downregulation of miR-204 expression defines a highly aggressive subset of Gr...
Abstract Genome-wide expression profiling studies have identified four core molecular subgroups of medulloblastoma: WNT, SHH, Group 3 and Group 4. Molecular markers are... -
Production of human pro-relaxin H2 in the yeast Pichia pastoris
Abstract Background Initially known as the reproductive hormone, relaxin was shown to possess other therapeutically useful properties that include extracellular matrix... -
MORG1+/− mice are protected from histological renal damage and inflammation i...
Abstract Background The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/− mice are protected... -
Asthmatic bronchial epithelial cells promote the establishment of a Hyalurona...
Abstract Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment... -
Inhaled nitric oxide for neonates with persistent pulmonary hypertension of t...
Abstract Background Substantial numbers of neonates with hypoxic respiratory failure (HRF) do not immediately respond to inhaled nitric oxide (iNO) and are often labeled as... -
Long-term safety and effectiveness of a continuous erythropoietin receptor ac...
Abstract Background This observational study investigated the safety and effectiveness of continuous erythropoietin receptor activator in patients with renal anemia in Japan.... -
Assessing the recovery from prerenal and renal acute kidney injury after trea...
Abstract Background Acute kidney injury (AKI) is an initial factor in many kidney disorders. Pre- and intra-renal AKI biomarkers have recently been reported. Recovery from AKI... -
Focusing light with orbital angular momentum by circular array antenna
We experimentally demonstrated focusing of light with orbital angular momentum (OAM) using an 8-element circular array of linear antennas. A spiral phase plate was used to... -
The impact of coexisting diabetes mellitus on clinical outcomes in patients w...
Abstract Background Idiopathic membranous nephropathy (IMN) is frequently coexisted with diabetes mellitus (DM). Few researches investigate clinical outcomes in IMN patients... -
Ginger relieves intestinal hypersensitivity of diarrhea predominant irritable...
Abstract Background Ginger or ginger extracts have been used in traditional medicine relieve pain caused by diarrhea predominant irritable bowel syndrome (IBS-D), but few data... -
Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activati...
Abstract Background Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role... -
Influence of dosing times on cisplatin-induced peripheral neuropathy in rats
Abstract Background Although cis-diamminedichloro-platinum (CDDP) exhibits strong therapeutic effects in cancer chemotherapy, its adverse effects such as peripheral neuropathy,... -
A case report of intravenous posaconazole in hepatic and renal impairment pat...
Abstract Background Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be... -
Prophylactic treatment of chronic renal disease in patients undergoing perito...
Abstract Background This study was performed to evaluate the clinical effectiveness of alternative strategies for the prevention and treatment of patients with chronic kidney... -
Percutaneous coronary intervention in diabetic versus non-diabetic patients w...
Abstract Background The target of this study was to explore the outcomes of percutaneous coronary intervention (PCI) in diabetic versus non-diabetic patients with prior coronary... -
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic act...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative...
