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A practical guide for probiotics applied to the case of antibiotic-associated...
Abstract Background Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with the use of broad spectrum antibiotics. Although a number of clinical studies... -
Increased β-Lactams dosing regimens improve clinical outcome in critically il...
Abstract Background Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was... -
Use of biologically-based complementary medicine in breast and gynecological ...
Abstract Background Biologically-based complementary medicines (BB-CAM) including herbs and nutritional supplements are frequently taken by breast- and gynecological cancer... -
Prioritising pathogens for the management of severe febrile patients to impro...
Abstract Background Severe febrile illness without a known source (SFWS) is a challenge for clinicians when deciding how to manage a patient, particularly given the wide... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
ALternatives To prophylactic Antibiotics for the treatment of Recurrent urina...
Abstract Background At least half of all adult women will experience infective cystitis (urinary tract infection: UTI) at least once in their life and many suffer from repeated... -
Production of human pro-relaxin H2 in the yeast Pichia pastoris
Abstract Background Initially known as the reproductive hormone, relaxin was shown to possess other therapeutically useful properties that include extracellular matrix... -
Evaluation of emodepside in laboratory models of human intestinal nematode an...
Abstract Background Helminthiases are very prevalent worldwide, yet their treatment and control rely on a handful of drugs. Emodepside, a marketed broad-spectrum veterinary... -
A double-masked placebo-controlled trial of azithromycin to prevent child mor...
Abstract Background Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested... -
Prospective trial examining safety and efficacy of microcurrent stimulation f...
Abstract Background Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants.... -
Minoxidil versus placebo in the treatment of arterial wall hypertrophy in chi...
Abstract Background Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome. Restoring sufficient... -
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin sn...
Abstract Background The African Programme for Onchocerciasis Control has proposed provisional thresholds for the prevalence of microfilariae in humans and of L3 larvae in... -
Behavioral interventions to reduce inappropriate antibiotic prescribing: a ra...
Abstract Background Clinicians frequently prescribe antibiotics inappropriately for acute respiratory infections (ARIs). Our objective was to test information technology-enabled... -
Epidemiology and burden of influenza in healthy children aged 6 to 35 months:...
Abstract Background Despite World Health Organization recommendations, in many countries young children are not targeted for influenza vaccination. To help inform influenza... -
Dengue virus causes changes of MicroRNA-genes regulatory network revealing po...
Abstract Background Dengue virus (DENV) is an increasing global health threat and associated with induction of both a long-lived protective immune response and... -
Clinical characteristics of 9 cancer patients with SARS-CoV-2 infection
Abstract In December 2019, a cluster of pneumonia cases was caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China. Cancer patients are a... -
How to eliminate taeniasis/cysticercosis: porcine vaccination and human chemo...
Abstract Background The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the... -
Evaluation of a medication monitor-based treatment strategy for drug-sensitiv...
Abstract Background Treatment for drug-sensitive tuberculosis (TB) is taken for at least 6 months and problems with adherence are common. Therefore, there is substantial... -
Infectious tenosynovitis with bloodstream infection caused by Erysipelothrix ...
Abstract Background Erysipelothrix rhusiopathiae is an established animal pathogen, which may cause infections in humans. It is a gram-positive rod and found in the tonsils or... -
Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmi...
Abstract Background Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical service. Therapies for AAV are imperfect with...
