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Impact of a continuing medical education meeting on the use and timing of urg...
Abstract Background Detection of cancer in general practice is challenging because symptoms are diverse. Even so-called alarm symptoms have low positive predictive values of... -
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inh...
Abstract Background Glossogyne tenuifolia (GT) (Hsiang-ju) is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the... -
What factors could influence physicians' management of women of childbearing ...
Abstract Background Pregnancy represents a complex challenge to clinicians treating women with chronic inflammatory disease. Many clinicians face a situation of heightened... -
ING3 promotes prostate cancer growth by activating the androgen receptor
Abstract Background The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of... -
ER, PgR, Ki67, p27Kip1, and histological grade as predictors of pathological ...
Abstract Background Neoadjuvant chemotherapy (NAC) with taxanes followed by fluorouracil, epirubicin, and cyclophosphamide (FEC), and concurrent trastuzumab is a potent regimen... -
Data integration to prioritize drugs using genomics and curated data
Abstract Background Genomic alterations affecting drug target proteins occur in several tumor types and are prime candidates for patient-specific tailored treatments.... -
Systematic literature review and meta-analysis on the epidemiology of propion...
Abstract Propionic acidemia (PA, OMIM #606054) is a serious, life-threatening, inherited, metabolic disorder caused by the deficiency of the mitochondrial enzyme... -
DNA methylation changes of whole blood cells in response to active smoking ex...
Abstract Active smoking is a major preventable public health problem and an established critical factor for epigenetic modification. In this systematic review, we identified 17... -
Return of genetic and genomic research findings: experience of a pediatric bi...
Abstract Background Assess process, uptake, validity and resource needs for return of actionable research findings to biobank participants. Methods Participants were... -
Once-daily fluticasone furoate/vilanterol versus twice daily combination ther...
Abstract Background Fluticasone furoate (FF)/vilanterol (VI) is a once-daily inhaled corticosteroid (ICS)/long-acting beta2 agonist (LABA) combination. FF/VI, 92/22mcg and... -
Long-term adverse event profile from four completed trials of oral eliglustat...
Abstract Background Eliglustat is a first-line oral treatment for adults with Gaucher disease type 1 who have an extensive, intermediate or poor CYP2D6 metabolizer phenotype... -
Drug poisoning deaths in the United States, 1999–2012: a statistical adjustme...
Abstract Background Drug poisoning mortality in the US has risen rapidly but the drugs involved are frequently unspecified on death certificates. Methods Reported and adjusted... -
Adverse drug reactions in older adults: a retrospective comparative analysis ...
Abstract Background Older adults are more prone to develop adverse drug reactions (ADRs) since they exhibit numerous risk factors. The first aim was to analyse the number of... -
Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF...
Abstract Background Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA... -
Hematoma block or procedural sedation and analgesia, which is the most effect...
Abstract Background Procedure sedation and analgesia (PSA) is often used to alleviate discomfort and to facilitate fracture reduction for patients with distal radius fracture in... -
Longitudinal analysis of healthy colon establishes aspirin as a suppressor of...
Abstract Background Colon cancer (CC) is the third most common cancer worldwide, highlighting the importance of developing effective prevention strategies. Accumulating evidence... -
Prognostic and predictive significance of long interspersed nucleotide elemen...
Abstract Background Hypomethylation of Long Interspersed Nucleotide Element-1 (LINE-1) is associated with worse prognosis in colorectal cancer (CRC). However, little is known... -
Low MiR-187 Expression Promotes Resistance to Chemoradiation Therapy In Vitro...
Abstract Esophageal adenocarcinoma (EAC) has a poor prognosis and is increasing in incidence in many Western populations. Neoadjuvant chemoradiation therapy (CRT) followed by... -
Retargeting azithromycin analogues to have dual-modality antimalarial activity
Abstract Background Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill... -
General practitioners’ perceptions of public reporting of institution and ind...
Abstract Background Public reporting of institution- and individual-level performance data has recently become a popular topic in the health care field. This study (1) evaluated...
