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Real-time monitoring of PtaHMGB activity in poplar transactivation assays
Abstract Background Precise control of gene expression is essential to synchronize plant development with the environment. In perennial plants, transcriptional regulation... -
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caen...
Abstract Background Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin... -
Dimerized translationally controlled tumor protein increases interleukin-8 ex...
Abstract Background Histamine releasing factor (HRF) is a unique cytokine known to regulate a variety of immune cells in late allergic reactions. In the previous study, we... -
Umbilical cord as a long-term source of activatable mesenchymal stromal cells...
Abstract Background Mesenchymal stromal cells (MSCs) are used in over 800 clinical trials mainly due to their immune inhibitory activity. Umbilical cord (UC), the second leading... -
Ethics of research on stem cells and regenerative medicine: ethical guideline...
Abstract Background Regenerative medicine plays a major role in biomedicine, and given the ever-expanding boundaries of this knowledge, numerous ethical considerations have been... -
Genome-wide profiling of transcribed enhancers during macrophage activation
Abstract Background Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional... -
CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer
Abstract Background Programmed death-ligand 1 (PD-L1) is an immunosuppressor that plays an important role in cancer treatments. Although majority of the studies demonstrated... -
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcription...
Abstract Background SIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our... -
Development of a novel strategy for robust synthetic bacterial promoters base...
Abstract Background Promoter evolution by synthetic promoter library (SPL) is a powerful approach to development of functional synthetic promoters to synthetic biology. However,... -
A possible role of microglia-derived nitric oxide by lipopolysaccharide in ac...
Abstract Background Toll-like receptor 4 (TLR4) plays a pivotal role in the pathophysiology of stroke-induced inflammation. Both astroglia and microglia express TLR4, and... -
Melicope ptelefolia leaf extracts exhibit antioxidant activity and exert anti...
Abstract Background Melicope ptelefolia is a well-known herb in a number of Asian countries. It is often used as vegetable salad and traditional medicine to address various... -
FoxO3 regulates hepatic triglyceride metabolism via modulation of the express...
Abstract Background Excessive intrahepatic lipid accumulation is the major characteristic of nonalcoholic fatty liver disease (NAFLD). We sought to identify the mechanisms... -
miR-375 mediates the CRF signaling pathway to regulate catecholamine biosynth...
Corticotropin-releasing-factor (CRF) is a key regulator of catecholamines (CATs) biosynthesis in the adrenal gland. Furthermore, miR-375 has been confirmed to be localized in... -
Therapeutic hypothermia in patients with coagulopathy following severe trauma...
Abstract Background Coagulopathy in traumatic brain injury (TBI) has been associated with poor neurological outcomes and higher in-hospital mortality. In general principle of... -
MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to l...
Abstract Background Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC)... -
Genome-scale mining of root-preferential genes from maize and characterizatio...
Abstract Background Modification of root architecture and improvement of root resistance to stresses can increase crop productivity. Functional analyses of root-specific genes... -
Risk factors and treatments for disseminated intravascular coagulation in neo...
Abstract Background Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this... -
De novo assembly and characterization of breast cancer transcriptomes identif...
Abstract Background Gene-fusion or chimeric transcripts have been implicated in the onset and progression of a variety of cancers. Massively parallel RNA sequencing (RNA-Seq) of... -
The active role of the transcription factor Sp1 in NFATc2-mediated gene regul...
Abstract Background Adenocarcinoma of the pancreas is one of the most aggressive tumor diseases affecting the human body. The oncogenic potential of pancreatic cancer is mainly... -
Combination chemotherapy with 5-fluorouracil and dacarbazine in advanced medu...
Combination chemotherapy with 5-fluorouracil and dacarbazine in advanced medullary thyroid cancer, a possible alternative?
