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Targeted nanopore sequencing for the identification of ABCB1 promoter translo...
Abstract Background Resistance to chemotherapy is the most common cause of treatment failure in acute myeloid leukemia (AML) and the drug efflux pump ABCB1 is a critical... -
Tadalafil 5 mg once daily for the treatment of erectile dysfunction during a ...
Abstract Background To explore the impact of patient-characteristics and relevant comorbidities on treatment continuation rates, effectiveness, and satisfaction in patients with... -
A randomized matched-pairs study of feasibility, acceptability, and effective...
Abstract Background This paper reports on the feasibility, acceptability, and effectiveness of an innovative implementation strategy named “systems consultation” aimed at... -
Bivariate genome-wide association study identifies novel pleiotropic loci for...
Abstract Background Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to... -
A mutation that blocks integrin α4β7 activation prevents adaptive immune-medi...
Abstract Background β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin... -
Use of a modified GreenScreen tool to conduct a screening-level comparative h...
Abstract Background Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater... -
Laboratory methods for case finding in human psittacosis outbreaks: a systema...
Abstract Background Psittacosis outbreak investigations require rapid identification of cases in order to trace possible sources and perform public health risk assessments. In... -
Opportunities for selective reporting of harms in randomized clinical trials:...
Abstract Background Adverse events (AEs) in clinical trials may be reported in multiple sources. Different methods for reporting adverse events across trials or across sources... -
Investigating the landscape of US orphan product approvals
Abstract Background The Orphan Drug Act was enacted in 1983 to encourage the development of drugs for rare diseases. Previous research has attempted to examine the impact of the... -
PS4DR: a multimodal workflow for identification and prioritization of drugs b...
Abstract Background During the last decade, there has been a surge towards computational drug repositioning owing to constantly increasing -omics data in the biomedical research... -
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promo...
Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a... -
Development of drug-inducible CRISPR-Cas9 systems for large-scale functional ...
Abstract Background Large-scale genetic screening using CRISPR-Cas9 technology has emerged as a powerful approach to uncover and validate gene functions. The ability to control... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
Central mechanisms of real and sham electroacupuncture in the treatment of ch...
Abstract Background Chronic low back pain (CLBP) is the most common chronic pain condition and is often resistant to conventional treatments. Acupuncture is a popular... -
Epigenetic regulation of transcription factor promoter regions by low-dose ge...
Abstract Background The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα)... -
Survival after recurrence in patients with gastric cancer who receive S-1 adj...
Abstract Background Some patients develop recurrence after curative resection and adjuvant chemotherapy. S-1, an oral fluoropyrimidine, is one of the standard regimens in... -
Therapeutic potential of mesenchymal stem cells and their exosomes in severe ...
Abstract The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing... -
High activity CAZyme cassette for improving biomass degradation in thermophiles
Abstract Background Thermophilic microorganisms and their enzymes offer several advantages for industrial application over their mesophilic counterparts. For example, a... -
VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy ...
Abstract Background Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma... -
Statin use and lung cancer risk in chronic obstructive pulmonary disease pati...
Abstract Background Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular...
