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Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
Tocilizumab in treatment-naïve patients with Takayasu arteritis: TOCITAKA Fre...
Abstract Objectives To assess long-term efficacy of tocilizumab in treatment-naive patients with Takayasu arteritis (TAK). Methods Prospective open-labeled trial in naïve... -
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogen...
Abstract Background We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g.,... -
Failure of target attainment of beta-lactam antibiotics in critically ill pat...
Abstract Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a challenge.... -
Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and s...
Abstract Background Cesium-137 (137Cs) is one of the major and most clinically relevant radionuclides of concern in a radiological dispersal device, “dirty bomb” scenario as... -
ALternatives To prophylactic Antibiotics for the treatment of Recurrent urina...
Abstract Background At least half of all adult women will experience infective cystitis (urinary tract infection: UTI) at least once in their life and many suffer from repeated... -
A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat,...
Abstract Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD)... -
The median effective dose (ED50) of cis-Atracurium for laryngeal mask airway ...
Abstract Background In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the cis-atracurium dosage for laryngeal mask insertion... -
Effects of a multi-strain probiotic supplement for 12 weeks in circulating en...
Abstract Background The present randomized clinical trial characterized the beneficial effects of a multi-strain probiotics supplementation on improving circulating endotoxin... -
Contribution of spinal cord glial cells to L. amazonensis experimental infect...
Abstract Background The cellular and molecular pathophysiological mecha\nisms of pain processing in neglected parasitic infections such as leishmaniasis remain unknown. The... -
Production of human pro-relaxin H2 in the yeast Pichia pastoris
Abstract Background Initially known as the reproductive hormone, relaxin was shown to possess other therapeutically useful properties that include extracellular matrix... -
Early switch from intravenous to oral antibiotic therapy in patients with can...
Abstract Background Neutropenic sepsis remains a common treatment complication for patients receiving systemic anti-cancer treatment. The UK National Institute for Health and... -
Isolation and functional validation of the CmLOX08 promoter associated with s...
Abstract Background Lipoxygenases (LOXs) play significant roles in abiotic stress responses, and identification of LOX gene promoter function can make an important contribution... -
Evaluation of emodepside in laboratory models of human intestinal nematode an...
Abstract Background Helminthiases are very prevalent worldwide, yet their treatment and control rely on a handful of drugs. Emodepside, a marketed broad-spectrum veterinary... -
Prevalence of neutropenia in children by nationality
Abstract Background A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo... -
A double-masked placebo-controlled trial of azithromycin to prevent child mor...
Abstract Background Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested... -
Prospective trial examining safety and efficacy of microcurrent stimulation f...
Abstract Background Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants.... -
Prospective clinical trial of Intravitreal aflibercept treatment for PolypoId...
Abstract Background Polypoidal choroidal vasculopathy is a variant of choroidal neovascularization and neovascular age related macular degeneration presenting with hemorrhagic... -
The role of RORα in salivary gland lesions in patients with primary Sjögren’s...
Abstract Background The orphan nuclear receptors retinoic acid-related receptor α and γt (RORα and RORγt) are critical in the development of T helper 17 (Th17) cells, and... -
Hematologic adverse events following palbociclib dose reduction in patients w...
Abstract Background Palbociclib improves outcomes for women with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer (HR+/HER2−...
