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Evaluation of emodepside in laboratory models of human intestinal nematode an...
Abstract Background Helminthiases are very prevalent worldwide, yet their treatment and control rely on a handful of drugs. Emodepside, a marketed broad-spectrum veterinary... -
Prevalence of neutropenia in children by nationality
Abstract Background A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo... -
A double-masked placebo-controlled trial of azithromycin to prevent child mor...
Abstract Background Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested... -
Prospective trial examining safety and efficacy of microcurrent stimulation f...
Abstract Background Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants.... -
Prospective clinical trial of Intravitreal aflibercept treatment for PolypoId...
Abstract Background Polypoidal choroidal vasculopathy is a variant of choroidal neovascularization and neovascular age related macular degeneration presenting with hemorrhagic... -
Hematologic adverse events following palbociclib dose reduction in patients w...
Abstract Background Palbociclib improves outcomes for women with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer (HR+/HER2−... -
Minoxidil versus placebo in the treatment of arterial wall hypertrophy in chi...
Abstract Background Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome. Restoring sufficient... -
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin sn...
Abstract Background The African Programme for Onchocerciasis Control has proposed provisional thresholds for the prevalence of microfilariae in humans and of L3 larvae in... -
Behavioral interventions to reduce inappropriate antibiotic prescribing: a ra...
Abstract Background Clinicians frequently prescribe antibiotics inappropriately for acute respiratory infections (ARIs). Our objective was to test information technology-enabled... -
Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pne...
Abstract Background Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystis pneumonia (PJP) in immunosuppressed patients with systemic... -
Epidemiology and burden of influenza in healthy children aged 6 to 35 months:...
Abstract Background Despite World Health Organization recommendations, in many countries young children are not targeted for influenza vaccination. To help inform influenza... -
Dengue virus causes changes of MicroRNA-genes regulatory network revealing po...
Abstract Background Dengue virus (DENV) is an increasing global health threat and associated with induction of both a long-lived protective immune response and... -
A systematic review of necrotising fasciitis in children from its first descr...
Abstract Background Necrotising fasciitis is a rapidly progressing soft-tissue infection with a low incidence that carries a relevant risk of morbidity and mortality. Although... -
Clinical characteristics of 9 cancer patients with SARS-CoV-2 infection
Abstract In December 2019, a cluster of pneumonia cases was caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China. Cancer patients are a... -
Human papillomavirus infection: protocol for a randomised controlled trial of...
Abstract Background Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are... -
How to eliminate taeniasis/cysticercosis: porcine vaccination and human chemo...
Abstract Background The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the... -
Characterizing and prognosticating chronic lymphocytic leukemia in the elderl...
Abstract Background Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the... -
Evaluation of a medication monitor-based treatment strategy for drug-sensitiv...
Abstract Background Treatment for drug-sensitive tuberculosis (TB) is taken for at least 6 months and problems with adherence are common. Therefore, there is substantial... -
Persistent hypoxemia after an asthma attack
Abstract The presence of an unknown intracardiac shunt due to a patent foramen ovale may be an unusual cause of hypoxemia. We report the case of a patient who presented... -
Antibiotic use in a tertiary healthcare facility in Ghana: a point prevalence...
Abstract Background The global rise and spread of antibiotic resistance is limiting the usefulness of antibiotics in the prevention and treatment of infectious diseases. The use...
