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The influence of hospital accreditation: a longitudinal assessment of organis...
Abstract Background A growing body of evidence supports the link between hospital organisational culture and health outcomes. Organisational culture is thus an essential... -
Impact of snus use in teenage boys on tobacco use in young adulthood; a cohor...
Abstract Background As smoking rates decreased, the use of Swedish snus (smokeless tobacco) concordantly increased in Norway. The role of snus as possible contributor to the... -
Genotype-phenotype correlations of adult-onset PLA2G6-associated Neurodegener...
Abstract Background Phospholipase A2 group VI (PLA2G6) mutations associated with neurodegeneration (PLAN) manifest as heterogeneous neurodegenerative disorders with variable... -
Factors associated with the development of septic shock in patients with cand...
Abstract Background Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very... -
Pleural effusion from intrathoracic migration of a ventriculo-peritoneal shun...
Abstract Background Pleural effusion is a rare complication of ventriculo-peritoneal (VP) cerebrospinal fluid (CSF) shunting and its diagnosis is difficult in patients with... -
Sepsis at ICU admission does not decrease 30-day survival in very old patient...
Abstract Background The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the... -
Co-producing public involvement training with members of the public and resea...
Plain english summary Members of the public share their views with researchers to improve health and social care research. Lay assessing is one way of doing this. This is where... -
Self- vs proxy-reported mobility using the mobility assessment tool-short for...
Abstract Background Mobility is fundamental to maintenance of an independent lifestyle and can predict clinical outcomes after health events among older individuals. However,... -
Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-indu...
Abstract Background Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection... -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
A multicenter randomized controlled trial of surgery alone or surgery with at...
Abstract Background Postoperative cancer recurrence is a major problem following curative surgery. In a previous retrospective study of lung cancer surgery, we reported that... -
Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosi...
Abstract Background Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the... -
Survey indicated that core outcome set development is increasingly including ...
Abstract Background There are numerous challenges in including patients in a core outcome set (COS) study, these can vary depending on the patient group. This study describes... -
Probiotics may not prevent the deterioration of necrotizing enterocolitis fro...
Abstract Background Probiotic therapy can reduce the incidence of NEC. Therapeutic use of probiotics after NEC diagnosis reduces the severity of NEC in preterm infants or... -
How to deal with a temporary suspension and restarting your trial: our experi...
Abstract Whilst the issues around early termination of randomised controlled trials (RCTs) are well documented in the literature, trials can also be temporarily suspended with... -
Efficient production of extracellular pullulanase in Bacillus subtilis ATCC60...
Abstract Background Bacillus subtilis has been widely used as a host for heterologous protein expression in food industry. B. subtilis ATCC6051 is an alternative expression host... -
Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation t...
Abstract Background Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging... -
Appendectomy, cholecystectomy and diagnostic laparoscopy conducted before pre...
Abstract Background Non-obstetric surgery conducted during pregnancy may increase the risk of adverse birth outcomes like small for gestational age, preterm birth, and... -
The association between physical activity and health-related quality of life ...
Abstract Background The quality of life for breast cancer survivors has become increasingly important because of their high survival rate and prolonged life expectancy. The... -
Systematic review of the relationships between sleep duration and health indi...
Abstract Background The objective of this systematic review was to examine for the first time the associations between sleep duration and a broad range of health indicators in...
