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Human laminin-111 and laminin-211 protein therapy prevents muscle disease pro...
Abstract Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result... -
Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation ...
Abstract Background High rates of recurrence and metastasis are the major cause of the poor outcomes for patients with lung cancer. In previous research, we have demonstrated... -
Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveal...
Abstract Background Idiopathic chronic diarrhea (ICD) is a common cause of morbidity and mortality among juvenile rhesus macaques. Characterized by chronic inflammation of the... -
Major differential gene regulation in Coxiella burnetii between in vivo and i...
Abstract Background Coxiella burnetii is the causative agent of the zoonotic disease Q fever. As it is an intracellular pathogen, infection by C. burnetii requires adaptation to... -
Analysis of the role of thrombomodulin in all-trans retinoic acid treatment o...
Abstract Background Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and... -
Elevated serum iron level is a predictor of prognosis in ICU patients with ac...
Abstract Background Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney... -
Microorganism-regulated mechanisms of temperature effects on the performance ...
Abstract Background Temperature is an important factor determining the performance and stability of the anaerobic digestion process. However, the microorganism-regulated... -
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Pre-announcement of symbiotic guests: transcriptional reprogramming by mycorr...
Abstract Background More than 80 % of all terrestrial plant species establish an arbuscular mycorrhiza (AM) symbiosis with Glomeromycota fungi. This plant-microbe interaction... -
Sex-specific IL-6-associated signaling activation in ozone-induced lung infla...
Abstract Background Acute ozone (O3) exposure has known deleterious effects on the respiratory system and has been linked with respiratory disease and infection. Inflammatory... -
Subfunctionalization of peroxisome proliferator response elements accounts fo...
Abstract Background In the duplication-degeneration-complementation (DDC) model, a duplicated gene has three possible fates: it may lose functionality through the accumulation... -
MIA-Sig: multiplex chromatin interaction analysis by signal processing and st...
Abstract The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets... -
RIF1 promotes human epithelial ovarian cancer growth and progression via acti...
Abstract Background Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the... -
Examining the role of unmeasured confounding in mediation analysis with genet...
Abstract Background In mediation analysis if unmeasured confounding is present, the estimates for the direct and mediated effects may be over or under estimated. Most methods... -
ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal tr...
Abstract Background Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role in... -
Enhanced extracellular expression of Bacillus stearothermophilus α-amylase in...
Abstract Background Our laboratory has constructed a Bacillus stearothermophilus α-amylase (AmyS) derivative with excellent enzymatic properties. Bacillus subtilis is generally... -
A toolset of constitutive promoters for metabolic engineering of Rhodosporidi...
Abstract Background Rhodosporidium toruloides is a promising host for the production of bioproducts from lignocellulosic biomass. A key prerequisite for efficient pathway... -
Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes
Abstract Objective This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes... -
Characterization of a strong and constitutive promoter from the Arabidopsis s...
Abstract Background Transgenic technology has become an important technique for crop genetic improvement. The application of well-characterized promoters is essential for... -
Pharmacological and functional similarities of the human neuropeptide Y syste...
Abstract Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in...
