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The impairment of small nerve fibers in severe sepsis and septic shock
Abstract Background A decrease of small nerve fibers in skin biopsies during the course of critical illness has been demonstrated recently. However, the diagnostic use of skin... -
The effects of green cardamom on blood glucose indices, lipids, inflammatory ...
Abstract Background The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of... -
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
The putative β-glucosidase BGL3I regulates cellulase induction in Trichoderma...
Abstract Background The filamentous fungus Trichoderma reesei (anamorph of Hypocrea jecorina) displays increased cellulase expression while growing on inducers such as lactose... -
Spirometric assessment of emphysema presence and severity as measured by quan...
Abstract Background The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway... -
Contacting out-of-hours primary care or emergency medical services for time-c...
Abstract Background Out-of-hours (OOH) healthcare services in Western countries are often differentiated into out-of-hours primary healthcare services (OOH-PC) and emergency... -
Sex-specific IL-6-associated signaling activation in ozone-induced lung infla...
Abstract Background Acute ozone (O3) exposure has known deleterious effects on the respiratory system and has been linked with respiratory disease and infection. Inflammatory... -
Micronutrient-rich dietary intake is associated with a reduction in the effec...
Abstract Background Informal recycling of electronic waste (e-waste) releases particulate matter (PM) into the ambient air. Human exposure to PM has been reported to induce... -
Subfunctionalization of peroxisome proliferator response elements accounts fo...
Abstract Background In the duplication-degeneration-complementation (DDC) model, a duplicated gene has three possible fates: it may lose functionality through the accumulation... -
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited ...
Abstract Background In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13... -
Extracellular vesicles derived from human ES-MSCs protect retinal ganglion ce...
Abstract Background Retinal and/or optic nerve injury is one of the leading causes of blindness due to retinal ganglion cell (RGC) degeneration. There have been extensive... -
Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes
Abstract Objective This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes... -
Prevalence and profile of adverse drug reactions in high-risk pregnancy: a co...
Abstract Background Commonly used drugs in pregnant women include antihypertensives, hypoglycemic agents, analgesics, antimicrobials, antiemetics and antispasmodics but the use... -
The neuroregenerative effects of topical decorin on the injured mouse cornea
Abstract Background The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any injury or pathology of the corneal... -
AHRR methylation in heavy smokers: associations with smoking, lung cancer ris...
Abstract Background A low level of methylation at cg05575921 in the aryl-hydrocarbon receptor repressor (AHRR) gene is robustly associated with smoking, and some studies have... -
Continuous hemofiltration improves the prognosis of bacterial sepsis complica...
Abstract Background Liver dysfunction is an independent risk factor for poor prognosis of patients with sepsis. The aim of this study is to evaluate the effects of continuous... -
ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchi...
Abstract Background A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased... -
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption t...
Abstract Background Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of... -
Retinal glial responses to optic nerve crush are attenuated in Bax-deficient ...
Abstract Background Retinal ganglion cell (RGC) soma death is a consequence of optic nerve damage, including in optic neuropathies like glaucoma. The activation of the innate... -
Association of adipokines with blood pressure, arterial elasticity and cardia...
Abstract Background Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We...
